Duovas 5/20 Tablet 14pcs

Uses of Duovas 5/20 Tablet

Olmesartan Medoxomil+Amlodipine is used for Hypertension (high blood pressure).

How does Duovas 5/20 Tablet work?

Amlodipine: A dihydropyridine calcium channel blocker that reduces peripheral vascular resistance and blood pressure by inhibiting the transmembrane influx of calcium ions into vascular smooth muscle.

Olmesartan Medoxomil: Blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking its binding to the AT1 receptor.

Side Effects of Duovas 5/20 Tablet

Common side effects of Duovas 5/20 Tablet may include:

• Headache
• Dizziness
• Fatigue
• Edema (swelling)
• Sore throat
• Constipation

Consult your doctor if any side effects worsen or persist.

Dosage & Administration of Duovas 5/20 Tablet

Initial therapy: Start with 5/20 mg once daily for 1 to 2 weeks and titrate as needed up to a maximum of 10/40 mg once daily. Consider reduced starting doses in elderly patients and caution in patients with hepatic impairment.

Interaction

The antihypertensive effect of angiotensin II receptor antagonists like Olmesartan Medoxomil may be reduced by NSAIDs, including selective COX-2 inhibitors. Close monitoring of blood pressure, renal function, and electrolytes is advised with combination therapy.

Contraindications

Duovas cannot be co-administered with Aliskiren in patients with diabetes.

Pregnancy & Lactation

Pregnancy Category D. Duovas is contraindicated in the second and third trimesters due to the risk of fetal death. It should be discontinued as soon as pregnancy is detected. Caution is advised during lactation.

Precautions & Warnings

Use with caution in volume- or salt-depleted patients, with severe aortic stenosis, and severe obstructive coronary artery disease. Safety and effectiveness in pediatric patients, renal impairment, and hepatic impairment have not been established.

Storage Conditions:

Store below 30°C, away from light, and keep out of reach of children.